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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Updated: Mar 20, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
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Use of Human Perivascular Stem Cells for Bone Regeneration

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Stem Cells in Bone Regeneration.

Graham G Walmsley1,2, Ryan C Ransom1,2, Elizabeth R Zielins1

  • 1Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Drive Room GK106, Stanford, CA, 94305-5461, USA.

Stem Cell Reviews and Reports
|June 3, 2016
PubMed
Summary
This summary is machine-generated.

Bone regeneration can fail in large defects or disease. This review covers bone healing, stem cell research, and cell-based bone tissue engineering, highlighting its potential in regenerative medicine.

Keywords:
BoneEngineeringRegenerationStem cellTissue

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Orthopedic Surgery

Background:

  • Bone possesses intrinsic regenerative capabilities.
  • This healing capacity is compromised by large defects and certain diseases.
  • Understanding bone healing mechanisms is crucial for therapeutic development.

Purpose of the Study:

  • To review the fundamental principles of bone healing.
  • To discuss the characterization of bone stem and progenitor cells.
  • To evaluate the progress of cell-based bone tissue engineering in clinical settings.

Main Methods:

  • Literature review of bone healing principles.
  • Analysis of studies on bone stem and progenitor cell populations.
  • Assessment of translational and clinical research in bone tissue engineering.

Main Results:

  • Key principles of bone healing have been elucidated.
  • Significant progress has been made in identifying and characterizing bone stem cells.
  • Translational and clinical studies show promise for cell-based bone regeneration.

Conclusions:

  • Cell-based strategies offer significant potential for bone repair.
  • Overcoming barriers to clinical implementation is essential for widespread application.
  • Bone tissue engineering holds promise for advancing regenerative medicine.