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Updated: Mar 20, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Stem Cells in Bone Regeneration
Graham G Walmsley1,2, Ryan C Ransom1,2, Elizabeth R Zielins1
1Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Drive Room GK106, Stanford, CA, 94305-5461, USA.
Abstract:
Bone has the capacity to regenerate and repair itself. However, this capacity may be impaired or lost depending on the size of the defect or the presence of certain disease states. In this review, we discuss the key principles underlying bone healing, efforts to characterize bone stem and progenitor cell populations, and the current status of translational and clinical studies in cell-based bone tissue engineering. Though barriers to clinical implementation still exist, the application of stem and progenitor cell populations to bone engineering strategies has the potential to profoundly impact regenerative medicine.
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