Jove
Visualize
Contact Us

Related Concept Videos

Inflammation01:38

Inflammation

63.9K
Overview
63.9K
Inflammatory Response01:28

Inflammatory Response

18.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
18.2K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.3K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

18.0K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
18.0K
T Cell Types and Functions01:24

T Cell Types and Functions

3.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.1K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.9K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Unraveling inflammatory pathways in sickle cell disease: molecular, cellular and translational insights.

Frontiers in immunology·2026
Same author

Anti-IL-18 immunotherapy decreases inflammatory and vaso-occlusive responses in mice with sickle cell disease.

Experimental hematology·2026
Same author

Caspase-1 activation drives vascular inflammatory processes and hypoperfusion in intravascular hemolysis.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Circulating Monocytes Contribute to Erythrocyte Clearance in Polycythemia Vera.

International journal of molecular sciences·2025
Same author

Acute intravascular haemolysis rapidly shifts the balance of angiogenic factors and accelerates neovascularization in vivo.

British journal of haematology·2025
Same author

Reduced GATA1 levels are associated with ineffective erythropoiesis in sickle cell anemia.

Haematologica·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 20, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K

Red cell DAMPs and inflammation.

Rafaela Mendonça1, Angélica A A Silveira1, Nicola Conran2

  • 1Hematology Center, School of Medicine, University of Campinas-UNICAMP, Barão Geraldo, Campinas, Sao Paulo, 13083-970, Brazil.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|June 3, 2016
PubMed
Summary
This summary is machine-generated.

Intravascular hemolysis releases damage-associated molecular patterns (DAMPs) that activate inflammation. These DAMPs, like heme, amplify inflammatory pathways, contributing to hemolytic disease symptoms and sickle cell complications.

Keywords:
DAMPsHemolysisInflammasomeRed blood cellsSickle cell diseaseToll-like receptor

More Related Videos

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay
11:27

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay

Published on: February 7, 2025

1.2K
Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
10:07

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins

Published on: March 17, 2023

2.5K

Related Experiment Videos

Last Updated: Mar 20, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K
Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay
11:27

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay

Published on: February 7, 2025

1.2K
Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
10:07

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins

Published on: March 17, 2023

2.5K

Area of Science:

  • Hematology
  • Immunology
  • Pathophysiology

Background:

  • Intravascular hemolysis is a common feature in various diseases, including anemias, infections, and transfusion reactions.
  • Red blood cell destruction releases damage-associated molecular patterns (DAMPs) into circulation.
  • Unneutralized DAMPs can activate multiple inflammatory pathways.

Purpose of the Study:

  • To investigate the role of intravascular hemolysis in activating inflammatory pathways.
  • To identify key red blood cell DAMPs involved in inflammation.
  • To understand the contribution of hemolysis to clinical manifestations of hemolytic diseases.

Main Methods:

  • The study reviews existing literature on intravascular hemolysis and DAMPs.
  • It analyzes the mechanisms by which heme and other DAMPs activate inflammatory cascades.
  • It correlates DAMP-mediated inflammation with clinical outcomes in hemolytic conditions.

Main Results:

  • Heme, a major red cell DAMP, activates toll-like receptor signaling, neutrophil extracellular trap formation, and inflammasome activation.
  • Other released DAMPs include heat shock proteins (Hsp70), interleukin-33, and Adenosine 5' triphosphate.
  • Hemolysis-induced inflammation contributes to clinical manifestations like pulmonary hypertension and leg ulcers.

Conclusions:

  • Intravascular hemolysis is a significant inflammatory mechanism.
  • Heme and other DAMPs amplify inflammation, exacerbating hemolytic disease pathology.
  • Hemolysis-induced inflammation plays a role in sickle cell disease complications, including endothelial activation and tissue injury.