The Path From Heart Failure to Cardiac Transplant
Related Experiment Video
Updated: Mar 20, 2026

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
Published on: February 14, 2022
Regi Freeman1, Erika Koerner, Courtney Clark
1Samuel and Jean Frankel Cardiovascular Center, University of Michigan Health System, Ann Arbor (Mss Freeman, Koerner, Clark, and Halabicky); and University of Michigan School of Nursing, Ann Arbor (Mss Freeman and Halabicky).
Insights
Heart failure treatments range from lifestyle changes to advanced therapies like cardiac transplant. This review details current heart failure management and cardiac transplant criteria.
Area of Science:
- Cardiology
- Transplant Surgery
Background:
- Heart failure affects millions annually, presenting progressive symptoms.
- Current treatments include lifestyle changes, medications, electrical therapies, and mechanical support.
Purpose of the Study:
- To outline current heart failure treatments.
- To detail cardiac transplant indications, contraindications, and evaluation.
- To provide information on donor heart allocation and characteristics.
Main Methods:
- Literature review of heart failure management strategies.
- Analysis of current guidelines for cardiac transplantation.
- Summary of donor heart selection and allocation processes.
Main Results:
- A spectrum of treatments exists for heart failure, tailored to disease stage.
- Cardiac transplant is the optimal treatment but limited by donor availability.
- Specific criteria guide patient selection and donor heart allocation.
Conclusions:
- Comprehensive management of heart failure involves diverse therapeutic options.
- Cardiac transplantation offers a life-saving option for eligible patients.
- Understanding transplant criteria and donor factors is crucial for successful outcomes.
Abstract:
Heart failure is a progressive and fatal disease impacting millions of American each year. Divided into stages, heart failure presents with progressive symptoms requiring a wide range of medical treatments. Treatments include diet and lifestyle changes, medications, electrical therapies (defibrillator and/or cardiac resynchronization therapy), as well as mechanical circulatory support. Cardiac transplant is the gold standard treatment of heart failure, although the availability of donors limits the utility of a cardiac transplant. This article outlines heart failure treatments and the indications, contraindications, and pretransplant evaluation for a cardiac transplant. Information on the allocation of donor hearts and donor characteristics is also included for the reader.
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