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Tolerance to the Intestinal Microbiota Mediated by ROR(γt)(+) Cells
1Center of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Center Munich, Biedersteiner Strasse 29, 80802 Munich, Germany.
Trends in Immunology
|June 4, 2016
Summary
The transcription factor ROR(γt) is crucial for gut immunity and lymphoid tissue development. Surprisingly, ROR(γt)-expressing cells also promote immune tolerance towards gut microbes.
Area of Science:
- Immunology
- Microbiology
- Molecular Biology
Background:
- Gut microbiota symbiosis requires host immune tolerance.
- The immune system can overreact to gut microbes.
- ROR(γt) is known to regulate immune cell development.
Purpose of the Study:
- To investigate the role of ROR(γt)-expressing cells in gut immune tolerance.
- To understand how ROR(γt) influences the balance between immunity and tolerance in the gut.
Main Methods:
- Analysis of ROR(γt) expression in gut immune cells.
- Studies on the function of ROR(γt)-expressing cells in mouse models.
- Investigating the impact of ROR(γt) on innate lymphoid cells type 3 (ILC3s) and type 17 T helper (Th17) cells.
Main Results:
- ROR(γt) is essential for lymphoid tissue organogenesis in the gut.
- ROR(γt)-expressing cells, including ILC3s and Th17 cells, play a role in gut immunity.
- Emerging evidence shows ROR(γt)-expressing cells contribute to immune tolerance mechanisms.
Conclusions:
- ROR(γt) has a dual role in the gut, promoting both immune responses and tolerance.
- Understanding ROR(γt) function is key to managing gut health and disease.
- Further research into ROR(γt) pathways could lead to new therapeutic strategies for inflammatory gut conditions.
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