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Related Experiment Video

Updated: Mar 20, 2026

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

Challenges in structural approaches to cell modeling.

Wonpil Im¹, Jie Liang², Arthur Olson³

¹Center for Computational Biology and Department of Molecular Biosciences, The University of Kansas, Lawrence, KS 66047, United States.

Journal of Molecular Biology

|June 4, 2016

Summary

This summary is machine-generated.

Computational modeling is advancing from single molecules to whole cells. This shift enables a dynamic, in vivo understanding of cellular components, crucial for biology and medicine.

Keywords:

cellular membranes chromosome modeling macromolecular crowding modeling of biological mesoscale protein interactions

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Last Updated: Mar 20, 2026

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Area of Science:

Computational Biology
Structural Biology
Cell Biology

Background:

Structural modeling of biomolecules is crucial for understanding mechanisms.
Progress has been made in modeling individual molecules and their interactions.
The field is expanding to model larger systems, including entire cells.

Purpose of the Study:

To review the state-of-the-art in structural modeling of cellular biology.
To illustrate the shift from modeling individual molecules to cellular systems.
To discuss future prospects in this emerging field.

Main Methods:

Review of diverse approaches in structural modeling.
Coverage of biological networks, protein complexes, and interactions.
Inclusion of cellular environment factors like crowding, membranes, and chromosomes.

Main Results:

Demonstration of a developing shift towards modeling cell biology.
Integration of various computational and experimental approaches.
Expert opinion on current advancements and future directions.

Conclusions:

Structural modeling of cells complements other computational methods for understanding cellular mechanisms.
This integrated approach is vital for a fundamental understanding of life at the molecular level.
Advancements promise significant applications in biology and medicine.