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Related Experiment Video

Updated: Mar 20, 2026

Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry

Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry

Published on: June 22, 2017

Circulating Monocytes in between the Gut and the Mind.

Kuti Baruch¹, Michal Schwartz¹

¹Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.

|June 4, 2016

Summary

Gut microbes influence brain health, impacting hippocampal neurogenesis. Möhle et al. identify Ly6C(hi) monocytes as key players in the gut-immune-brain axis, linking diet to new neuron formation.

Area of Science:

Neuroscience
Immunology
Microbiology

Background:

Hippocampal neurogenesis is vital for cognitive functions and is influenced by external factors.
The gut microbiota's role in modulating brain function, particularly neurogenesis, is increasingly recognized but poorly understood.
Existing research highlights the gut-immune-brain axis as a critical communication pathway.

Purpose of the Study:

To elucidate the mechanisms connecting gut microbiota to hippocampal neurogenesis.
To identify specific immune cells involved in the gut-immune-brain axis.
To understand how external factors influence the brain via the gut-immune system.

Main Methods:

Utilized mouse models to investigate the gut-immune-brain axis.
Employed flow cytometry and genetic lineage tracing to identify and track immune cell populations.

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Last Updated: Mar 20, 2026

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Published on: June 22, 2017

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Published on: February 2, 2011

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

Assessed markers of hippocampal neurogenesis and immune cell infiltration.

Main Results:

Ly6C(hi) monocytes were identified as crucial mediators in the gut-immune-brain axis.
These monocytes were shown to infiltrate the brain and influence hippocampal neurogenesis.
The study provides evidence for a direct link between gut microbiota, immune responses, and brain plasticity.

Conclusions:

Ly6C(hi) monocytes play a significant role in mediating the effects of gut microbiota on hippocampal neurogenesis.
This finding sheds light on the complex interplay between the gut, immune system, and brain.
The gut-immune-brain axis represents a promising therapeutic target for cognitive and neurological disorders.