Related Experiment Video
Updated: Mar 20, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
904
The Orthology Ontology: development and applications
Jesualdo Tomás Fernández-Breis1, Hirokazu Chiba2, María Del Carmen Legaz-García3
1Departamento de Informática y Sistemas, Universidad de Murcia, IMIB-Arrixaca, Murcia, 30071, Spain. jfernand@um.es.
Journal of Biomedical Semantics
|June 5, 2016
Summary
A new Orthology Ontology (ORTH) standardizes gene function and evolutionary relationships across diverse genomic databases. This enables linked data and improved computational analysis in biomedical research.
Area of Science:
- Comparative genomics
- Bioinformatics
- Evolutionary biology
Background:
- Comparative genomic analysis offers significant opportunities in biomedical research.
- Orthology analysis is crucial for understanding gene evolution and function.
- Variations in orthology databases hinder data sharing and integration.
Purpose of the Study:
- To develop a standardized framework for orthology data.
- To facilitate the creation of shareable and interoperable orthology datasets.
- To enhance the exploitation of orthology resources in biomedical research.
Main Methods:
- Construction of the Orthology Ontology (ORTH) using Web Ontology Language (OWL).
- Assessment of the ontology's quality and application to existing orthology datasets.
- Implementation of best practices in ontology development.
Main Results:
- The ORTH provides a common semantic framework for orthology content.
- Development of Linked Orthology Datasets is enabled through this standardization.
- Demonstrated feasibility of creating shareable orthology datasets.
Conclusions:
- The Orthology Ontology standardizes orthology representation, improving data sharing.
- This ontology facilitates the development of advanced tools like meta-predictors.
- Further applications of ORTH will enhance its utility in biomedical research.
Related Concept Videos
01:20Anatomical Terminology
28.4K
Knowledge of anatomy is essential to understand human biology and medicine. Anatomists and health care professionals use standard terminology to describe the human body with more precision and no ambiguity. Anatomical terms have mostly Greek and Latin-derived roots. Because these languages are rarely used in conversation, the meaning of words remains the same. Each term is made up of a root in between the prefixes and suffixes. The root of a term often refers to an organ, tissue, or condition,...
28.4K
01:22Language Development
1.0K
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
1.0K
01:12The Hyoid Bone
6.2K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
6.2K
01:21Tooth Anatomy
2.6K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
2.6K
01:18Classification of Bones
11.7K
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
11.7K
01:31Taxonomy
92.6K
Taxonomy is the science of defining and naming groups of biological organisms based on shared characteristics. It uses a hierarchy of increasingly inclusive categories with Latin names. The smallest units of taxonomy, species and genus, are used to assign a formal, taxonomic name to each species in a system. This classification system, referred to as binomial nomenclature, was formalized by Carolus Linnaeus in the 18th century.
Hierarchy of Taxonomy
The hierarchy that Carolus Linnaeus first...
Hierarchy of Taxonomy
The hierarchy that Carolus Linnaeus first...
92.6K