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Related Experiment Videos

Advanced topical formulations (ATF).

Jonathan Hadgraft1, Majella E Lane1

  • 1Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.

International Journal of Pharmaceutics
|June 5, 2016
PubMed
Summary
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Improving topical formulations requires understanding diffusion principles. This review examines challenges in topical delivery and proposes a rational approach for advanced product development to enhance active bioavailability.

Area of Science:

  • Dermatology
  • Pharmaceutics
  • Physical Chemistry

Background:

  • Topical formulations are widely used for cosmetic, protective, and therapeutic skin applications.
  • Despite historical use of creams and ointments, the bioavailability of active ingredients from topical preparations is typically low (1-2%).
  • Poor bioavailability limits the efficacy of many topical treatments.

Purpose of the Study:

  • To investigate the reasons behind the low performance of conventional topical formulations.
  • To propose a rational strategy for developing advanced topical formulations based on diffusion principles.
  • To highlight the importance of understanding both the active ingredient and the vehicle's behavior in the skin.

Main Methods:

  • Critical examination of current research and development methodologies for topical formulations.
Keywords:
Advanced topical formulationCrystallisationPenetrationSkinSupersaturation

Related Experiment Videos

  • Application of Fick's laws of diffusion to guide the design of advanced formulations.
  • Emphasis on analyzing the fate of both the active ingredient and the formulation vehicle.
  • Discussion of emerging analytical techniques for real-time skin delivery assessment.

    • Main Results:

    • Identified key factors contributing to poor bioavailability in topical preparations.
    • Outlined a diffusion-based approach for rational topical formulation design.
    • Stressed the necessity of understanding the physical chemistry of formulations and skin interactions.
    • Highlighted the role of advanced analytical techniques in optimizing topical delivery.

    Conclusions:

    • Optimizing topical product performance necessitates a deep understanding of skin penetration and active ingredient release.
    • Advanced topical formulation development relies on a rational, science-driven approach.
    • Integrating knowledge of physical chemistry and sophisticated analytical methods is crucial for creating effective topical products.