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MRI-compatible bone phantom for evaluating ultrasonic thermal exposures.

Georgios Menikou1, Marinos Yiannakou2, Christos Yiallouras3

  • 1City University, London, UK.

Ultrasonics
|June 5, 2016
PubMed
Summary

A novel MRI-compatible bone phantom was developed for focused ultrasound (FUS) protocol evaluation. This phantom accurately mimics bone and tissue interfaces, reducing the need for animal models in focused ultrasound surgery research.

Keywords:
BoneCancerMRIUltrasound

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Acoustic Therapy

Background:

  • Focused Ultrasound Surgery (FUS) is gaining traction for palliative care in advanced bone cancer.
  • Developing accurate phantoms is crucial for evaluating FUS protocols, especially for bone applications.
  • Current methods may require extensive animal testing, highlighting the need for effective simulation tools.

Purpose of the Study:

  • To develop a magnetic resonance imaging (MRI) compatible bone phantom.
  • To enable evaluation of focused ultrasound (FUS) protocols for bone applications.
  • To provide a viable alternative to animal models in FUS research.

Main Methods:

  • A 3D-printed ABS plastic femur bone model was created from CT scans.
  • A novel agar-silica-evaporated milk gel mimicked surrounding skeletal muscle tissue.
  • MR thermometry was employed to assess FUS exposure on the bone phantom.

Main Results:

  • The phantom's agar gel exhibited T1 and T2 relaxation times of 776ms and 66ms at 1.5T.
  • MR thermometry revealed temperature increases near the bone-phantom/gel interface.
  • These temperature distributions closely resembled those observed at real bone-tissue interfaces during FUS ablation.

Conclusions:

  • The developed MRI-compatible bone phantom is a functional tool for evaluating FUS protocols.
  • The phantom accurately simulates thermal effects at bone-tissue interfaces.
  • This innovation can significantly reduce reliance on animal models for FUS research and development.