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Trefoil factor 3 related to gastrointestinal failure in pediatric critical illness
1Department of Thoracic, the First Hospital, Lanzhou University, No. 1 Donggang West Road, 730000, Lanzhou, Gansu Province, China.
Insights
Elevated serum trefoil factor 3 (TFF3) levels may predict gastrointestinal failure (GIF) in critically ill children. TFF3 shows promise as a prognostic factor and may aid mucosal repair in pediatric critical illness.
Area of Science:
- Pediatric Critical Care Medicine
- Gastroenterology
- Biomarker Discovery
Background:
- Gastrointestinal failure (GIF) is a critical complication in pediatric critical illness.
- Identifying reliable biomarkers for GIF is crucial for timely management.
- Trefoil factor 3 (TFF3) is implicated in gastrointestinal mucosal integrity.
Purpose of the Study:
- To investigate the association between serum TFF3 concentrations and the development of GIF in pediatric patients.
- To evaluate TFF3 as a potential prognostic marker for GIF in this population.
Main Methods:
- Serum TFF3 levels were measured using ELISA in 137 pediatric patients.
- Patients were categorized into control, critical illness without GIF, and critical illness with GIF groups.
- Statistical analyses included group comparisons and Cox proportional hazards modeling.
Main Results:
- Serum TFF3 concentrations were significantly higher in patients who developed GIF prior to its occurrence.
- TFF3 levels correlated with gastrointestinal function scores in patients with GIF.
- Serum TFF3 concentrations at the time of GIF onset and 48 hours later served as significant prognostic factors.
Conclusions:
- Serum TFF3 may serve as a valuable predictive biomarker for GIF in pediatric critical illness.
- TFF3 potentially plays a protective role in the mucosal repair mechanisms within the gastrointestinal tract.
Background:
To determine the relationship between the serum concentration of trefoil factor 3 (TFF3) and gastrointestinal failure (GIF) in pediatric critical illness in order to provide knowledge for disease management.
Materials And Methods:
We enrolled 137 cases and divided them into three groups, including a control group (group A), critical illness without GIF (group B), and critical illness with GIF (group C). The serum TFF3 concentration was determined by ELISA and compared among the groups.
Results:
Serum TFF3 concentrations measured before the occurrence of GIF in group C were significantly higher than in groups A and B (P<0.01). Under the conditions of GIF in group C, serum TFF3 concentration was significantly related to the gastrointestinal tract function score (r=-0.712). Cox's proportional hazards model analysis showed that the serum TFF3 concentrations at the time of occurrence of GIF, and 48hours later, could be used as prognostic factors in critically ill pediatric patients with GIF (r=1.443 and 1.872, respectively).
Conclusion:
TFF3 may play an important role in predicting GIF in pediatric critical illness and has a protective function in the mucosal repair process.
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