Polymorphic eruption of pregnancy

Area of Science:

• Dermatology
• Obstetrics
• Pregnancy-related dermatoses

Background:

• Polymorphic eruption of pregnancy (PEP), also known as pruritic urticarial papules and plaques of pregnancy (PUPPP), is a specific dermatosis of pregnancy.
• It is a benign, self-limited skin disorder with characteristic clinical features.

Purpose of the Study:

• To review the key features, diagnosis, pathogenesis, and management of polymorphic eruption of pregnancy.
• To differentiate PEP from other pregnancy dermatoses like pemphigoid gestationis.

Main Methods:

• Review of clinical features for diagnosis.
• Discussion of histopathology and immunofluorescence studies for differential diagnosis.
• Exploration of current theories on PEP pathogenesis.

Main Results:

• PEP commonly affects primigravidas, appearing in the third trimester.
• The condition typically resolves near delivery and is associated with multiple gestation.
• Clinical presentation is key for diagnosis, as histopathology is nonspecific.

Conclusions:

• Polymorphic eruption of pregnancy is a benign condition with no associated maternal or fetal risks.
• Diagnosis relies on clinical presentation, with immunofluorescence aiding differentiation from pemphigoid gestationis.
• Treatment for PEP is primarily symptomatic.