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Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
Published on: August 17, 2022
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Cardiac Lymphoma.
Jean Jeudy1, Allen P Burke2, Aletta Ann Frazier3
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA.
Radiologic Clinics of North America
|June 7, 2016
Summary
Primary cardiac lymphoma is rare, mostly diffuse large B-cell lymphomas in older men. While common in disseminated nodal disease, primary heart lymphoma is uncommon, often affecting the right heart with pericardial effusions.
Area of Science:
- Cardiovascular Pathology
- Hematologic Oncology
Background:
- Cardiac lymphoma can occur in up to 25% of patients with disseminated nodal lymphoma.
- Primary cardiac lymphoma, however, is a rare clinical presentation.
Purpose of the Study:
- To review the characteristics of cardiac and pericardial lymphoma.
- To highlight the typical presentation and pathology of this rare condition.
Main Methods:
- Review of existing literature on cardiac and pericardial lymphoma.
- Analysis of epidemiological and clinical features from reported cases.
Main Results:
- The majority of cardiac lymphomas are diffuse large B-cell lymphomas.
- These typically affect immunocompetent older males, with a 2:1 male-to-female ratio.
- Cardiac lymphomas commonly involve the right heart, particularly the right atrium, with epicardial and pericardial infiltration.
- Pericardial effusions and implants are frequent, and the disease is often multifocal within the heart, sparing cardiac valves.
Conclusions:
- Primary cardiac lymphoma is a rare entity, distinct from secondary involvement in nodal disease.
- Understanding its predilection for the right heart and specific histological type is crucial for diagnosis and management.
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