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A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

Engineering cell-based therapies to interface robustly with host physiology.

Kelly A Schwarz¹, Joshua N Leonard²

¹Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd., Evanston, IL 60208, United States.

Advanced Drug Delivery Reviews

|June 9, 2016

Summary

This summary is machine-generated.

Engineered cell therapies use programmed cells for disease treatment. Improving how these therapies perform in the body is key for future advancements in robust cell-based treatments.

Keywords:

Biosensors Cell-based therapies Gene circuits Mammalian synthetic biology

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Area of Science:

Biotechnology
Cellular Engineering
Therapeutic Development

Background:

Engineered cell-based therapies leverage natural cellular functions like migration and secretion for disease treatment.
Advancements in intracellular and extracellular sensors allow programming cells for specific responses to environmental cues.

Purpose of the Study:

To review current capabilities and identify needs for developing robust cell-based therapies.
To propose a framework for evaluating and achieving consistent therapeutic efficacy across diverse patients and implementations.

Main Methods:

Review of existing sensors and outputs for cell-based therapies.
Analysis of key advancements and current limitations in the field.
Development of a conceptual framework for assessing in vivo performance.

Main Results:

A comprehensive overview of available sensors and outputs for engineered cell therapies.
Identification of gaps in current technology for achieving robust in vivo performance.
A proposed framework to guide the development of therapies with consistent efficacy.

Conclusions:

Robustness, defined as consistent therapeutic efficacy across patients, is crucial for advancing cell-based therapies.
Further technological development is needed to enhance the in vivo performance of engineered cells.
The proposed framework can aid in evaluating and optimizing cell-based therapeutic strategies.