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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Nano-based strategies to overcome p-glycoprotein-mediated drug resistance

Mehri Niazi1, Parvin Zakeri-Milani2, Saeedeh Najafi Hajivar1

  • 1a Student Research Committee, Faculty of Advanced Medical Sciences and Research Center for Pharmaceutical Nanotechnology , Tabriz University of Medical Sciences , Tabriz , Iran.

Expert Opinion on Drug Metabolism & Toxicology
|June 9, 2016
PubMed
Abstract

Insights

Nanotechnology offers solutions to overcome multi-drug resistance (MDR) in cancer chemotherapy. Novel nano-based systems effectively deliver agents to combat P-glycoprotein-mediated MDR, improving drug bioavailability and cancer cell sensitivity.

Area of Science:

  • Oncology
  • Nanotechnology
  • Drug Delivery

Background:

  • Chemotherapy is a key cancer treatment, but its efficacy is often limited by multi-drug resistance (MDR).
  • P-glycoprotein-mediated MDR is a major challenge, causing cancer cells to extrude drugs and become insensitive to treatment.
  • Developing effective strategies to overcome MDR is crucial for improving patient outcomes.

Purpose of the Study:

  • To review and highlight the role of nano-based drug delivery systems in overcoming P-glycoprotein-mediated MDR.
  • To discuss various nanomedical approaches for enhancing the delivery of MDR-reversing agents into cancer cells.
  • To explore the potential of nanotechnology in revolutionizing cancer treatment by addressing drug resistance.

Main Methods:

  • Investigated nano-based systems for delivering MDR-reversing agents, including siRNA, antibodies, natural extracts, and inhibitors.
  • Examined the use of hard and soft nanoparticles as drug delivery vehicles.
  • Considered novel approaches like cell-penetrating peptides for enhanced intracellular delivery.

Main Results:

  • Nano-based delivery systems demonstrate increased efficacy in overcoming P-glycoprotein-mediated MDR.
  • These systems enhance the intracellular delivery of agents designed to reverse drug resistance.
  • Nanotechnology provides a promising platform for improving the bioavailability and effectiveness of chemotherapy.

Conclusions:

  • Nanotechnology is increasingly vital for overcoming cancer drug resistance.
  • Targeting drug efflux transporters and silencing MDR genes are key areas of research.
  • Nanomedical approaches hold significant potential to become a cornerstone of future cancer therapy.
Keywords:
CancerP-glycoproteinchemotherapymulti drug resistancenanomedical approaches

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