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Molindone: effects in pigeons responding under conditional discrimination tasks.

M J Picker1, J P Cleary, K Berens

  • 1Department of Psychology, University of North Carolina, Chapel Hill 27599-3270.

Pharmacology, Biochemistry, and Behavior
|February 1, 1989
PubMed
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The neuroleptic drug molindone impaired accuracy in pigeons, with effects varying across different behavioral procedures. This highlights the need for diverse assays to understand neuroleptic drug actions.

Area of Science:

  • Behavioral pharmacology
  • Neuroscience
  • Animal models

Background:

  • Neuroleptic drugs are used to treat psychosis.
  • Understanding their behavioral effects is crucial for therapeutic application.
  • Pigeons serve as a model organism for studying cognitive processes.

Purpose of the Study:

  • To investigate the behavioral effects of the neuroleptic agent molindone in pigeons.
  • To compare molindone's impact across different conditional discrimination procedures.
  • To assess the utility of various behavioral assays for characterizing neuroleptic drug actions.

Main Methods:

  • Pigeons were trained on three procedures: fixed-consecutive-number (FCN 8-SD and FCN 8), delayed matching-to-sample (DMTS) with varying delays, and repeated acquisition of behavioral chains (RA).

Related Experiment Videos

  • Molindone was administered at different doses to assess its effects on accuracy and response rates.
  • Behavioral performance was quantified under each procedure to determine drug-induced changes.

    • Main Results:

    • Molindone decreased accuracy under FCN 8 more than FCN 8-SD.
    • Accuracy decrements in DMTS were proportional to the delay interval (0, 2, 8 seconds).
    • Molindone reduced accuracy in RA with minimal impact on correct response numbers, showing the largest deficits under FCN 8 and RA procedures.

    Conclusions:

    • Molindone exhibits differential effects on accuracy depending on the behavioral assay used.
    • The findings underscore the importance of employing a variety of behavioral tests to fully characterize neuroleptic drug actions.
    • This battery of tests may aid in assessing the neurochemical mechanisms of neuroleptic compounds.