[Gastric perfusion in the rat--a method for determining gastric secretion]
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1Klinik und Poliklinik für Chirurgie, Martin-Luther-Universität Halle-Wittenberg.
Die Pharmazie
|January 1, 1989
Abstract:
The response of the 3 postulated receptors in the parietal cell was investigated by means of a perfusion model in the rat. It was compared the effect of cimetidine and atropine on pentagastrin, histamine and carbachol stimulated gastric acid secretion with a control group. Atropine blocked the carbachol stimulation totally but did not effect pentagastrin and histamine stimulation. Cimetidine inhibited all stimulations. This method is a model for study of drugs influences of the gastric secretion.