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[Sarcoma of the spleen with MDM2 expression]
1Institut für Pathologie, Klinikum Lippe GmbH, Detmold und Lemgo, Röntgenstraße 18, 32756, Detmold, Deutschland. Torsten.Hansen@klinikum-lippe.de.
Der Pathologe
|June 9, 2016
Summary
A rare splenic tumor initially suspected as dedifferentiated liposarcoma due to MDM2 expression was ultimately diagnosed as follicular dendritic cell sarcoma (FDCS) based on CD21 and CD23 markers.
Area of Science:
- Oncology
- Pathology
- Surgical Pathology
Background:
- Primary sarcomas of the spleen are exceptionally rare.
- Spindle cell tumors can present diagnostic challenges.
Observation:
- A 69-year-old male presented with abdominal symptoms and a splenic tumor identified via CT scan.
- Histology revealed a spindle cell sarcoma with lymphoid infiltrates.
Findings:
- MDM2 expression and amplification were detected, initially suggesting dedifferentiated liposarcoma.
- Strong CD21 and CD23 expression led to the final diagnosis of follicular dendritic cell sarcoma (FDCS).
Implications:
- MDM2 expression can be a diagnostic pitfall in spindle cell tumors.
- Distinguishing FDCS from dedifferentiated liposarcoma requires careful immunohistochemical analysis.
