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Updated: Mar 19, 2026

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Modeling and Imaging 3-Dimensional Collective Cell Invasion
Published on: December 7, 2011
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Visualizing Cancer Cell Chemotaxis and Invasion in 2D and 3D
Olivia Susanto1, Andrew J Muinonen-Martin2, Max Nobis1
1CR-UK Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
Methods in Molecular Biology (Clifton, N.J.)
|June 9, 2016
Abstract
None:
We describe three chemotaxis assays-Insall chambers, circular invasion assays, and 3D organotypic assays-that are particularly appropriate for measuring migration of cancer cells in response to gradients of soluble attractants. Each assay has defined advantages, and together they provide the best possible quantitative assessment of cancer chemotaxis.

