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The prevalence and risk factors of stroke in patients with chronic schizophrenia

Ying Liang1, Jian Huang1, Jingbin Tian2

  • 1National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, People's Republic of China.

Neuropsychiatric Disease and Treatment
|June 9, 2016
PubMed

Insights

Stroke risk is elevated in Chinese patients with chronic schizophrenia. Key risk factors include advanced age, female sex, smoking, polypharmacy, high medication doses, obesity, and hypertension.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cardiovascular Medicine

Background:

  • Chronic schizophrenia is associated with increased cerebrovascular disease risk.
  • Understanding stroke prevalence and risk factors in this population is crucial for preventative strategies.

Purpose of the Study:

  • To determine the stroke risk in Chinese patients diagnosed with chronic schizophrenia.
  • To identify specific risk factors contributing to stroke in this patient cohort.

Main Methods:

  • A large-scale, cross-sectional survey involving 363 patients with chronic schizophrenia.
  • Patients were categorized into stroke and control groups for comparative analysis.
  • Clinical assessments included the Positive and Negative Syndrome Scale and detailed questionnaires on demographics and medical history.

Main Results:

  • The prevalence of stroke among patients with chronic schizophrenia was found to be 16.5%.
  • Significant differences were observed between stroke and control groups regarding age, sex, smoking status, medication combinations and doses, negative symptom scores, BMI, waist circumference, and systolic blood pressure.
  • Multivariate analysis identified age, sex, smoking, combined medication, high doses, BMI, and systolic blood pressure as significant stroke risk factors.

Conclusions:

  • Stroke prevalence is notably high in Chinese patients with chronic schizophrenia.
  • Identified risk factors for stroke in this population include older age, female gender, smoking, polypharmacy, high drug dosages, obesity, and hypertension.
Abstract

Keywords:
riskrisk factorsschizophreniastroke

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