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A practical overview of pediatric atopic dermatitis, part 2: triggers and grading

Nanette B Silverberg1

  • 1Mount Sinai St. Luke's-Roosevelt Hospital and Beth Israel Medical Centers of the Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Cutis
|June 9, 2016
PubMed

Insights

This review discusses triggers and the atopic march in childhood atopic dermatitis (AD). It highlights changes in AD

Area of Science:

  • Pediatric Dermatology
  • Immunology
  • Allergy

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition in children.
  • Understanding AD triggers and its natural history is crucial for effective management.
  • The "atopic march" describes the progression of allergic diseases.

Purpose of the Study:

  • To review triggers for atopic dermatitis (AD) onset and flares in pediatric patients.
  • To explore the role of AD in the atopic march.
  • To discuss the utility of grading systems in AD therapeutic development and clinical practice.

Main Methods:

  • Literature review of studies on atopic dermatitis triggers.
  • Analysis of the relationship between AD and other atopic conditions.
  • Examination of current grading systems used in AD research and care.

Main Results:

  • Identified key environmental and intrinsic factors that trigger AD appearance and exacerbations.
  • Demonstrated the significant role of early-onset AD in initiating the atopic march.
  • Highlighted the evolving natural history of AD, with increased persistence rates.

Conclusions:

  • Effective management requires understanding specific triggers and the atopic march.
  • Grading systems are essential tools for developing new AD therapeutics and standardizing clinical care.
  • Counseling guardians and patients on the persistent nature of AD is vital.

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