Related Experiment Video
Updated: Mar 19, 2026
Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
Interventional Treatment of Pulmonary Valve Stenosis: A Single Center Experience
Shpend Idrizi1, Ivan Milev1, Planinka Zafirovska1
1Special Hospital for Surgical Diseases "Filip Vtori", Skopje, Republic of Macedonia.
Insights
Percutaneous pulmonary valvuloplasty is a highly effective treatment for pulmonary stenosis, showing good short- and mid-term outcomes in patients, including children. This minimally invasive procedure significantly reduces pressure gradients and improves heart function.
Area of Science:
- Cardiology
- Interventional Cardiology
- Pediatric Cardiology
Background:
- Percutaneous pulmonary valvuloplasty (PPV) is the established treatment for pulmonary valve stenosis.
- This study evaluates the effectiveness and safety of PPV.
Purpose of the Study:
- To present experience with PPV technique.
- To assess immediate and mid-term effectiveness.
- To determine the complication rate of PPV.
Main Methods:
- A total of 43 patients underwent PPV.
- 33 patients (74%) were children aged 1 month to 15 years.
Main Results:
- The procedure was successful in 90% of patients (38/43).
- Mean transvalvular gradient decreased from 91.2 mmHg to 39.1 mmHg.
- One major complication (pericardial effusion) occurred; 13.9% required a second intervention. Right heart function improved significantly during follow-up (2-13 years).
Conclusions:
- PPV is an effective treatment for pulmonary stenosis.
- The procedure yields good short- and mid-term results.
- PPV demonstrates significant improvements in right heart function and echocardiographic parameters.
Background:
Percutaneous pulmonary valvuloplasty is well established treatment of choice in pulmonary valve stenosis.
Aim:
The aim of our study was to present our experience with the interventional technique, its immediate and mid-term effectiveness as well as its complication rate.
Material And Methods:
The study included 43 patients, where 33 (74%) of them were children between the age of 1 month and 15 years.
Results:
The procedure was successful in 38 patients or 90%. Mean peak to peak transvalvular gradient was reduced from 91.2 mmHg (55-150 mmHg) to 39.1 mmHg (20-80 mmHg). Follow- up of patients was between 2 and 13 years and included echocardiographic evaluation of pulmonary valve gradient, right heart dimensions and function as well as assessment of pulmonary regurgitation. We experienced one major complication pericardial effusion in a 5 months old child that required pericardiocenthesis. Six patients (13.9%) required a second intervention. During the follow up period there was significant improvement of right heart function and echocardiography parameters. Mild pulmonary regurgitation was noted in 24 (55%) patients, and four (9%) patients developed moderate regurgitation, without affecting the function of the right ventricle.
Conclusions:
Percutaneous pulmonary valvuloplasty is an effective procedure in treatment of pulmonary stenosis with good short and mid-term results.
More Related Videos
05:31Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
Published on: June 8, 2022
11:20A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position
Published on: April 1, 2022
Related Concept Videos
01:26Mitral Stenosis III: Medical Management
01:25Mitral Regurgitation III: Medical Management
01:27Mitral Stenosis IV: Nursing Management
01:25Aortic Regurgitation III: Medical Management
01:22Mitral Stenosis I: Introduction
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...