Disrupted Bone Metabolism in Long-Term Bedridden Patients
Keiko Eimori1,2, Naoto Endo2, Seiji Uchiyama3
1Divisions of Pediatric Orthopedic Surgery, Nishi-Niigata Chuo National Hospital, Niigata, Japan.
Plos One
|June 9, 2016
Summary
Long-term bed confinement in patients leads to unique bone metabolism changes, increasing osteoporosis and fracture risks. Further confinement alters these bone metabolic abnormalities, highlighting the need for tailored treatments.
Area of Science:
- Orthopedics
- Metabolic Bone Disease
Background:
- Bedridden patients face risks of osteoporosis and fractures.
- Long-term bone metabolic processes in these patients are not well understood.
Purpose of the Study:
- To investigate the effects of long-term bed confinement on bone metabolism.
Main Methods:
- Studied 36 patients bedridden from birth.
- Assessed bone mineral density and bone metabolism markers.
- Monitored changes over 12 years in 17 patients.
Main Results:
- Reduced bone mineral density and elevated osteocalcin and urine N-terminal telopeptide (NTX) levels observed.
- Osteocalcin and NTX levels negatively correlated with bedridden duration.
- Follow-up showed decreased osteocalcin, parathyroid hormone, and increased 25(OH) vitamin D.
Conclusions:
- Patients with prolonged bed confinement exhibit distinct bone metabolic abnormalities.
- These abnormalities are influenced by continued immobility.
- Personalized treatment strategies targeting unique metabolic changes are crucial.
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