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SQSTM1 Mutations and Glaucoma.

Todd E Scheetz1,2, Ben R Roos1,2, Frances Solivan-Timpe1,2

  • 1Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

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|June 9, 2016
PubMed
Summary
This summary is machine-generated.

Mutations in the sequestosome (SQSTM1) gene are not a common cause of normal tension glaucoma (NTG). This study found no significant association between SQSTM1 mutations and NTG in patients and controls.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Cell Biology

Background:

  • Glaucoma is a leading cause of irreversible blindness globally.
  • Normal tension glaucoma (NTG) occurs without elevated intraocular pressure.
  • Mutations in OPTN and TBK1 are linked to familial NTG and involve autophagy.

Purpose of the Study:

  • To investigate if mutations in the sequestosome (SQSTM1) gene are associated with normal tension glaucoma (NTG).
  • To test the hypothesis that SQSTM1 mutations contribute to NTG pathogenesis.

Main Methods:

  • Sanger sequencing of SQSTM1 in 308 NTG patients and 157 controls.
  • Whole exome sequencing of SQSTM1 in 1098 population controls.
  • Analysis of 17 detected non-synonymous mutations for significant differences between cases and controls.

Main Results:

  • A total of 17 non-synonymous SQSTM1 mutations were identified.
  • No statistically significant difference in mutation frequency was observed between NTG patients and control groups.
  • The distribution of SQSTM1 mutations did not significantly differ between cases and controls.

Conclusions:

  • SQSTM1 mutations do not appear to be a common genetic cause of normal tension glaucoma.
  • Further research may be needed to explore other potential genetic factors in NTG.