Human Saliva Collection Devices for Proteomics: An Update
Zohaib Khurshid1, Sana Zohaib2, Shariq Najeeb3
1College of Dentistry, King Faisal University, Al-Hofuf, Al-Ahsa 31982, Saudi Arabia. drzohaibkhurshid@gmail.com.
International Journal of Molecular Sciences
|June 9, 2016
Summary
Saliva is increasingly used for disease diagnosis due to new, sensitive technologies and easy-to-use collection devices. This advancement promises future prediction and diagnosis of oral and systemic diseases through salivary proteomics.
Area of Science:
- Biomarker Discovery
- Proteomics
- Clinical Diagnostics
Background:
- Saliva is a valuable diagnostic specimen offering insights into oral and systemic health.
- Recent technological advancements have enhanced the sensitivity of analyte detection in saliva.
- Standardized, non-invasive saliva collection devices have become readily available.
Purpose of the Study:
- To review recent developments in saliva specimen collection devices.
- To highlight advances in the application of saliva for disease diagnosis and proteomics.
- To discuss the potential of salivary proteomics in predicting and diagnosing diseases.
Main Methods:
- Review of recent literature on saliva diagnostics and proteomics.
- Description of advancements in saliva collection technologies.
- Analysis of emerging applications of salivary analysis.
Main Results:
- Significant improvements in saliva collection devices enable simple, safe, and non-invasive sampling.
- New technologies allow for the detection of lower analyte concentrations in saliva.
- Salivary proteomics shows promise for early disease detection.
Conclusions:
- Standardized saliva collection and sensitive analytical technologies are transforming diagnostics.
- Salivary proteomics is poised to play a crucial role in predicting and diagnosing a range of diseases, including cancer and infectious diseases.
- The field anticipates major advancements in the next decade, leveraging saliva as a key diagnostic fluid.
