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Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration

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Aldehydes and Ketones with Water: Hydrate Formation

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Introduction
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Related Experiment Video

Updated: Mar 19, 2026

Methane Hydrate Crystallization on Sessile Water Droplets

Methane Hydrate Crystallization on Sessile Water Droplets

Published on: May 26, 2021

Propane Clathrate Hydrate Formation Accelerated by Methanol.

Jaruwan Amtawong¹, Jin Guo¹, Jared S Hale¹

¹Department of Chemistry, University of California , Irvine, California 92697, United States.

The Journal of Physical Chemistry Letters

|June 9, 2016

Summary

Methanol significantly accelerates propane clathrate hydrate (CH) formation even at low concentrations. This discovery aids efficient gas storage and provides insights into CH formation mechanisms.

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Area of Science:

Physical Chemistry
Materials Science

Background:

Methanol's dual role as inhibitor and catalyst in clathrate hydrate (CH) formation is under investigation.
Understanding CH kinetics is crucial for applications like gas storage.

Purpose of the Study:

To quantitatively study the kinetics of propane CH formation at 253 K.
To investigate the effect of methanol doping on CH formation rates and initiation pressure.

Main Methods:

Propane gas reacted with <75 μm ice particles doped with varying methanol concentrations at 253 K.
Quantitative kinetic measurements of propane uptake into CHs.

Main Results:

Methanol significantly accelerates propane CH formation kinetics, even at low doping levels (1 methanol per 10,000 water molecules).
Enhanced uptake rates and reduced initiation pressure observed with methanol doping.
The acceleration effect is pronounced even with minimal methanol presence.

Conclusions:

Small quantities of methanol act as potent catalysts for propane clathrate hydrate formation.
Findings suggest potential for more efficient CH production for gas storage applications.
The observed acceleration may refine mechanistic understanding of methanol's role in CH formation under different conditions.