INTRAVITREAL TRIAMCINOLONE IN SUSAC SYNDROME
Juan B Yepez1, Felipe A Murati, Michele Pettito
1*Vitreoretinal Surgery Department, Clinica de Ojos, Maracaibo, Venezuela; and †Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Retinal Cases & Brief Reports
|June 9, 2016
Summary
Intravitreal triamcinolone effectively treated ocular symptoms in a Susac Syndrome patient when systemic corticosteroids were delayed. This targeted approach offers a potential solution for acute visual disturbances in this rare condition.
Area of Science:
- Ophthalmology
- Neurology
- Endocrinology
Background:
- Susac Syndrome is a rare condition characterized by encephalopathy, visual disturbances, and sensorineural hearing loss.
- Ocular manifestations often include branch retinal artery occlusions.
- Standard treatment involves systemic corticosteroids, which may be delayed in some cases.
Observation:
- A 23-year-old woman presented with sudden visual loss, neurological symptoms, and hearing loss, consistent with Susac Syndrome.
- Ophthalmic findings included bilateral branch retinal artery occlusions.
- MRI confirmed characteristic lesions in the corpus callosum.
Findings:
- A single intravitreal injection of triamcinolone (4 mg) was administered to the affected eye.
- Ocular symptoms and visual loss resolved within one week.
- Neurological and auditory symptoms persisted, indicating the need for systemic therapy.
Implications:
- Intravitreal triamcinolone can provide rapid resolution of ocular manifestations in Susac Syndrome.
- This treatment may be a valuable adjunctive therapy when initiating systemic corticosteroids is delayed.
- Further research is warranted to explore the role of localized corticosteroid therapy in Susac Syndrome management.
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