Related Experiment Video

Updated: Mar 19, 2026

Multi-Stream Perfusion Bioreactor Integrated with Outlet Fractionation for Dynamic Cell Culture
10:00

Multi-Stream Perfusion Bioreactor Integrated with Outlet Fractionation for Dynamic Cell Culture

Published on: July 20, 2022

2.9K

Piecewise function parameters as responses of the design of experiment in the development of a pulsatile release

Andreea Loredana Vonica-Gligor, Ioan Tomuţă, Sorin E Leucuţa

    Acta Pharmaceutica (Zagreb, Croatia)
    |June 10, 2016
    PubMed

    More Related Videos

    Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles07:32

    Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

    Published on: August 28, 2015

    12.1K
    Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study20:24

    Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

    Published on: January 31, 2014

    17.2K

    Related Concept Videos

    Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

    Modified-Release Drug Delivery Systems: Drug Release Characteristics

    Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
    138
    Modified-Release Drug Delivery Systems: Influencing Factors01:20

    Modified-Release Drug Delivery Systems: Influencing Factors

    Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
    105
    Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

    Modified-Release Drug Delivery Systems: Rate-Programmed II

    Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
    72
    Modified-Release Drug Delivery Systems: Classification01:23

    Modified-Release Drug Delivery Systems: Classification

    Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
    201
    Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

    Modified-Release Drug Delivery Systems: Rate-Programmed I

    Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
    82
    Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

    Biopharmaceutical Factors Influencing Drug Product Design: Overview

    Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
    410