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Brentuximab vedotin in relapsed/refractory Hodgkin lymphoma: An updated review of published data from the named

P L Zinzani1, S Sasse2, J Radford3

  • 1Institute of Hematology and Medical Oncology, 'L. & A. Seràgnoli', University of Bologna, Bologna, Italy.

Critical Reviews in Oncology/Hematology
|June 10, 2016
PubMed

Brentuximab vedotin was available via named patient program (NPP) to patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) or systemic anaplastic large-cell lymphoma in ∼60 non-US/Canadian countries, before local approval. Published results were examined recently; through systematic literature review, we identified 12 new NPP publications. Most (10/12) publications included new NPP data describing 8 unique cohorts (N=480; all R/R HL) and new participating countries. Overall response rates were 58-80%, and complete remission rates were 10-40%. With median follow-up of 9.5-26 months, median progression-free survival was 5-10.5 months and median overall survival (OS) had not been reached in most cohorts; 1- and 2-year OS was 67-76% and 58-67%, respectively. Tolerability was as expected from previous reports. Despite intrinsic bias and heterogeneous cohorts, this update supports previous findings showing comparable efficacy and tolerability of brentuximab vedotin between real-world practice and phase 2 trial results in R/R HL.

Keywords:
Antibody-drug conjugateBrentuximab vedotinCD30Hodgkin lymphomaNamed patient program

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