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Updated: Mar 19, 2026

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

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Triclosan antimicrobial polymers.

Richard C Petersen¹

¹Department of Biomaterials and Restorative Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.

AIMS Molecular Science

|June 10, 2016

Summary

This summary is machine-generated.

Triclosan

Keywords:

Antimicrobial bond entanglements bond rotation computational chemistry mechanomolecular polymer secondary bonding strength toughness viscosity

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Area of Science:

Polymer Science and Materials Chemistry
Antimicrobial Agent Research
Computational Chemistry

Background:

Triclosan's molecular properties, specifically ether bond rotations, influence its behavior in polymer systems.
Understanding these rotations is key to explaining triclosan's impact on material characteristics.

Purpose of the Study:

To analyze triclosan's fluctuating molecular energies and ether bond rotations using computational chemistry.
To elucidate how these molecular dynamics affect polymer properties and compatibility.

Main Methods:

Conformational computational chemistry analyses were employed to study triclosan's molecular dynamics.
The study reviewed existing data on triclosan's antimicrobial mechanisms.

Main Results:

Triclosan's bond rotations enhance polymer toughness, strength, and blend compatibilization.
It offers stability, low aqueous solubility, and extended antimicrobial lifetime in polymers.
Rotations reduce resin viscosity, aiding polymer blending and processing.

Conclusions:

Triclosan acts as a multifunctional additive, providing antimicrobial, toughening, and wetting benefits.
Its molecular dynamics disrupt bacterial membranes and interfere with cell division.
Triclosan can be incorporated into polymers via various methods for diverse applications.