Related Experiment Video
Updated: Mar 19, 2026
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
[Immunotherapy for brain tumors: obstacles and perspectives]
Abstract:
Glioblastomas are highly aggressive tumors. Their prognosis remain poor despite standard therapies combining surgery, radiation and temozolomide based chemotherapy. Among innovating strategies, there is a major interest for immunotherapy. During the past 3 decades, there has been a general scepticism concerning the efficacy of this approach. But the latest achievements, such as immune checkpoint inhibitors in solid tumors, and adoptive cell therapy in hematologic malignancies, have radically changed the face of the field and have already an impact on the daily practice. To which extent these advances have an impact for brain tumors also? This article aims to present the principal clinical applications of the various immune therapies currently under investigation in neurooncology and give an insight on the future perspectives in the field.
Insights
Immunotherapy offers new hope for glioblastoma, a highly aggressive brain tumor. Recent advances show promise for improving patient outcomes beyond standard treatments.
Area of Science:
- Neuro-oncology
- Immunotherapy
- Cancer research
Context:
- Glioblastomas are aggressive brain tumors with poor prognosis.
- Standard treatments (surgery, radiation, chemotherapy) have limited efficacy.
- Immunotherapy is an emerging strategy with growing interest.
Purpose:
- To review current clinical applications of immunotherapy in neuro-oncology.
- To discuss the impact of recent immunotherapy advancements on brain tumors.
- To provide insights into future perspectives for brain tumor immunotherapy.
Summary:
- Glioblastomas remain challenging due to their aggressive nature and poor prognosis despite conventional therapies.
- Recent breakthroughs in immunotherapy, including immune checkpoint inhibitors and adoptive cell therapy, have transformed cancer treatment.
- This review explores the evolving role and potential of immunotherapy in treating brain tumors.
Impact:
- Immunotherapy advancements are shifting the paradigm in cancer treatment, offering new hope for patients with brain tumors.
- Understanding the clinical applications and future directions of immunotherapy is crucial for advancing neuro-oncology.
- This work highlights the potential of immunotherapy to improve outcomes for glioblastoma patients.
More Related Videos
11:15Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
06:15Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Related Concept Videos
01:27Tumor Immunotherapy
01:30Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
02:56Treatment Resistant Cancers
02:56Treatment Resistent Cancers
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...