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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
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Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study
Sirio Cocozza1, Antonietta Canna1, Roberta Lanzillo2
11 Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
The British Journal of Radiology
|June 11, 2016
Summary
This study found no significant differences in neck vein stenosis or blood flow between multiple sclerosis (MS) patients and healthy controls using MRI. Extracranial venous abnormalities do not appear to be related to MS disease.
Area of Science:
- Neuroimaging
- Vascular Medicine
- Neurology
Background:
- Previous research suggested a link between neck venous drainage abnormalities and multiple sclerosis (MS).
- Quantitative MRI methods offer a way to assess venous structure and blood flow in the neck.
Purpose of the Study:
- To evaluate venous stenosis and blood flow in neck vessels of MS patients compared to healthy controls (HC).
- To investigate potential correlations between these vascular findings and clinical variables in MS.
Main Methods:
- Phase-contrast MRI was used to assess flow rates and cross-sectional areas of neck arteries and veins in 45 MS patients and 40 HC.
- Data were analyzed using unpaired t-tests for group comparisons and Spearman's test for correlations with clinical parameters.
Main Results:
- Internal jugular vein (IJV) stenosis was observed in 51.1% of MS patients and 45.0% of HC, with no significant difference between groups.
- No significant differences in any measured flow rates or cross-sectional areas were found between MS patients and HC.
- No correlations were identified between MRI-derived vascular measures and clinical variables in MS patients.
Conclusions:
- Quantitative MRI analysis indicates that extracranial venous alterations, including stenosis and flow abnormalities, are not associated with multiple sclerosis.
- The findings challenge the hypothesis that neck venous drainage abnormalities play a role in the pathogenesis or clinical presentation of MS.
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