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Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
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Ischemic Heart Disease: Overview01:17

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Updated: Mar 19, 2026

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
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Left Ventricular Diastolic Dysfunction in Ischemic Stroke: Functional and Vascular Outcomes.

Hong-Kyun Park1, Beom Joon Kim1, Chang-Hwan Yoon2

  • 1Department of Neurology and Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea.

Journal of Stroke
|June 11, 2016
PubMed
Summary

Left ventricular diastolic dysfunction, indicated by elevated E/e' ratios, is linked to worse outcomes after ischemic stroke. This includes increased risk of functional dependence, death, and recurrent vascular events within one year.

Keywords:
Acute ischemic strokeFunctional outcomeLeft ventricular diastolic dysfunctionRecurrent vascular event

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Area of Science:

  • Cardiology
  • Neurology
  • Echocardiography

Background:

  • Left ventricular (LV) diastolic dysfunction affects 15%-25% of the population.
  • Its impact on functional recovery and recurrent vascular events post-ischemic stroke is understudied.

Purpose of the Study:

  • To investigate the association between LV diastolic dysfunction and outcomes after acute ischemic stroke.
  • To evaluate the role of E/e' ratio in predicting functional recovery and vascular events.

Main Methods:

  • Retrospective observational study of 2,827 ischemic stroke patients.
  • Echocardiographic assessment of LV diastolic dysfunction using E/e' ratio within 1 month post-stroke.
  • Prospective collection of functional recovery and vascular event data at 3 months and 1 year.

Main Results:

  • Elevated E/e' (≥15) was observed in 13% of patients.
  • Patients with E/e' ≥15 showed increased odds of functional dependence or death at 3 months (aOR 1.73) and 1 year (aOR 1.47).
  • Higher E/e' was also associated with increased odds of 1-year vascular events (aOR 1.65).

Conclusions:

  • Left ventricular diastolic dysfunction is significantly associated with adverse functional outcomes.
  • LV diastolic dysfunction predicts an increased risk of composite vascular events up to 1 year post-stroke.