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Published on: July 20, 2022
Correlation between impedance cardiography and 6 min walk distance in atrial fibrillation patients
Ling Ding1, Xiao-Qing Quan1, Shu Zhang1
1Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Insights
This study found that cardiac output measured by impedance cardiography positively correlates with the 6-minute walk distance in atrial fibrillation patients. This finding may help assess exercise capacity in AF patients.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- The relationship between impedance cardiography (ICG) and 6-minute walk distance (6MWD) in atrial fibrillation (AF) patients is not well understood.
- AF is a common arrhythmia affecting cardiac function and exercise capacity.
Purpose of the Study:
- To investigate the correlation between hemodynamic parameters measured by ICG and 6MWD in patients with AF.
- To compare hemodynamic profiles and exercise capacity between AF patients and controls.
Main Methods:
- 49 subjects (21 AF, 28 controls) were recruited.
- Hemodynamic parameters (CO, SV, SVR, etc.) and 6MWD were measured.
- Pearson correlation analysis was used to assess relationships.
Main Results:
- AF patients exhibited lower cardiac output (CO), higher systemic vascular resistance index (SSVRI), and reduced 6MWD compared to controls.
- NT-pro brain natriuretic peptide (NT-pro BNP) levels were significantly higher in the AF group.
- CO, stroke volume (SV), left stroke work (LSW), and left stroke work index (LSWI) positively correlated with 6MWD in AF patients.
Conclusions:
- AF patients have impaired hemodynamics and reduced exercise capacity compared to those in sinus rhythm.
- ICG-derived CO is a significant positive predictor of 6MWD in AF patients, suggesting its utility in assessing functional status.
Background:
The correlation between impedance cardiography (ICG) and 6 min walk distance (6MWD) in atrial fibrillation (AF) patients remains unknown.
Methods:
We recruited 49 subjects in the study (21 AF patients and 28 patients without AF) and estimated hemodynamic parameters: cardiac output (CO), stroke volume (SV), stroke volume index (SVI), left stroke work (LSW), left stroke work index (LSWI), stroke systemic vascular resistance (SSVR), stroke systemic vascular resistance index (SSVRI); 6MWD, left ventricle ejection fraction (LVEF), NT-pro brain natriuretic peptide (NT-pro BNP) for the two groups.
Results:
The AF group have apparently lower CO (2.26 ± 0.14 VS 4.11 ± 0.20 L/min, p = 0.039) and distinctly higher SVR (677.60 ± 69.10 VS 344.41 ± 22.98 dynes/cm(5), p = 0.001), SSVRI (396.97 ± 36.80 VS 199.01 ± 11.72 dynes/cm(5)/m(2), p < 0.001) than the control group. NT-pro BNP (1409.48 ± 239.90 VS 332.59 ± 68.85 pg/ml, p = 0.001) in the AF group was significantly higher than the control group and 6MWD (264.33 ± 14.55 VS 428.79 ± 29.98 m, p < 0.001) in the AF group was lower than the control group. There was no significant difference in LVEF between the two groups (62.67 ± 7.62 % VS 63.93 ± 5.03 %, p = 0.470). Pearson correlation analysis revealed that CO (R = 0.494, p = 0.023), SV (R = 0.633, p = 0.002), LSW (R = 0.615, p = 0.003) and LSWI (R = 0.491, p = 0.024) significantly correlated positively with 6MWD in AF patients.
Conclusions:
AF patients had lower cardiac output, shorter 6MWD and higher NT-pro BNP than patients with sinus rhythm. The cardiac output measured by impedance cardiography significantly correlated positively with 6MWD in AF patients.
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