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Worsening Hypoxia Post Lung Transplant: What has Changed?
Ashish H Shah1, Andrew Leventhal1, Eric Horlick1
1Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Heart, Lung & Circulation
|June 11, 2016
Summary
Platypnoea-orthodeoxia causes breathlessness and low oxygen levels when upright. The exact cause of this rare condition, involving heart shunting, remains unclear.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Physiology
Background:
- Platypnoea-orthodeoxia is a rare clinical syndrome.
- It presents as breathlessness and hypoxia that worsens in an upright position.
Observation:
- The condition is often associated with an inter-atrial shunt or pulmonary vascular malformation.
- The precise anatomical or physiological mechanisms driving the right-to-left shunt, especially against typical pressure gradients, are not well understood.
Findings:
- The underlying pathology involves alterations in cardiac or pulmonary vasculature.
- The initiation of a right-to-left shunt in this specific postural context is a key area of investigation.
Implications:
- Clarifying the pathophysiology could lead to improved diagnostic strategies.
- Understanding the mechanisms may reveal novel therapeutic targets for patients with platypnoea-orthodeoxia.
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