Related Experiment Video
Updated: Mar 19, 2026

High-Throughput Total Internal Reflection Fluorescence and Direct Stochastic Optical Reconstruction Microscopy Using a Photonic Chip
Published on: November 16, 2019
Fourier ptychographic reconstruction using Poisson maximum likelihood and truncated Wirtinger gradient
Liheng Bian1, Jinli Suo1, Jaebum Chung2
1Department of Automation, Tsinghua University, Beijing 100084, China.
This study introduces a new Fourier ptychographic microscopy (FPM) reconstruction method to improve image quality. The novel approach effectively reduces noise and errors in computational imaging, enhancing Fourier ptychographic (FP) reconstructions.
Area of Science:
- Computational Imaging
- Optics and Photonics
- Image Reconstruction
Background:
- Fourier ptychographic microscopy (FPM) is a computational imaging technique enabling high space-bandwidth product imaging.
- FPM reconstruction involves phase retrieval from low-resolution intensity images to recover a high-resolution spectrum.
- Real-world FPM measurements are degraded by noise (Gaussian, Poisson, speckle) and pupil location errors, impacting reconstruction quality.
Purpose of the Study:
- To develop a novel Fourier ptychographic (FP) reconstruction method robust to common measurement degenerations.
- To enhance the accuracy and quality of reconstructed images in FPM systems.
- To provide an efficient and effective solution for overcoming noise and errors in FP reconstruction.
Main Methods:
- A gradient descent optimization framework is employed for FP reconstruction.
- Poisson maximum likelihood is utilized for improved signal modeling.
- Truncated Wirtinger gradient is applied for effective error removal and noise reduction.
Main Results:
- The proposed FP reconstruction method demonstrates superior performance compared to existing state-of-the-art algorithms.
- Simulated and real experimental data validate the effectiveness of the new method in handling noise and errors.
- Significant improvements in image reconstruction quality were observed using the developed technique.
Conclusions:
- The novel FP reconstruction method offers a robust solution for addressing degenerations in FPM.
- The technique enhances the reliability and accuracy of computational imaging reconstructions.
- The source code is available for non-commercial use, promoting further research and application.
Related Concept Videos
Reconstruction of Signal using Interpolation
Parseval's Theorem for Fourier transform
To understand Parseval's theorem, it is essential to first comprehend how signal energy is typically calculated. When considering a...
Poisson's And Laplace's Equation
Trigonometric Fourier series
The trigonometric Fourier series specifically expresses a periodic function with a defined period T using sine...
Convergence of Fourier Series
The Gibbs phenomenon refers to the persistent oscillations and overshoots that occur near discontinuities...
Linear Approximation in Frequency Domain
In contrast, nonlinear systems do not inherently possess these properties. However, for small deviations around an operating point, a nonlinear system can often be approximated as linear....

