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Synthesis of models of the BC ring systems of MPC1001 and MPC1001F
Shuai Dong1, Kiran Indukuri, Derrick L J Clive
1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, P. R. China. jinminggao@nwsuaf.edu.cn.
Abstract:
Piperazinedione 13, representing the BC rings of the anti-prostate cancer fungal metabolite MPC1001, was prepared by a route in which a sulfur-stabilized carbanion derived from 22 cyclizes onto the terminal ester of the pendant chain attached to N(1). Another model, 14, was synthesized by cyclization of an α-ketoamide nitrogen onto an ester; 14 represents the BC rings of MPC1001F.
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