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Theophylline-isoniazid interaction.

J Torrent1, I Izquierdo, R Cabezas

  • 1School of Medicine, Autonomous University of Barcelona, Spain.

DICP : the Annals of Pharmacotherapy
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

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Isoniazid, used for tuberculosis, can increase theophylline levels in asthma patients, leading to toxicity. Stopping isoniazid helps theophylline levels return to normal.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Drug Interactions

Background:

  • Theophylline is a common bronchodilator for asthma.
  • Isoniazid is a primary drug for tuberculosis treatment.
  • Hepatic microsomal enzymes play a role in drug metabolism.

Observation:

  • A patient with asthma and tuberculosis experienced theophylline toxicity during isoniazid therapy.
  • Theophylline levels exceeded the therapeutic range while co-administered with isoniazid.
  • Symptoms of theophylline toxicity were observed.

Findings:

  • Isoniazid administration led to elevated theophylline plasma concentrations.
  • Discontinuation of isoniazid resulted in a gradual decline of theophylline levels.
  • The study suggests isoniazid may inhibit theophylline elimination.

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Implications:

  • Clinicians should monitor theophylline levels in patients also receiving isoniazid.
  • This interaction highlights the importance of considering drug metabolism when prescribing multiple medications.
  • Awareness of this interaction can prevent theophylline toxicity in co-treated patients.