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Inhibitory Effects of Ellagic Acid on Glucosyltransferases from Mutans Streptococci
S Sawamura1,2, Y Tonosaki1, S Hamada1,2
1a Nippon Flour Mills Co., Ltd., Central Laboratory , Nurumizu, Atsugi , Kanagawa 243 , Japan.
Abstract:
Ellagic acid and its derivatives were found to abrogate the enzymatic activity of the glucosyltransferases (GTases) of mutans streptococci. These compounds preferentially inhibited the water-soluble glucan synthesis by GTase of Streptococcus mutans MT8148 and inhibited the water-insoluble glucan synthesis by GTase of Streptococcus sobrinus 6715. This inhibition resulted in a reduction of cellular adherence of mutans streptococci to a glass surface.
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