Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical Research Collaboration

Area of Science:

• Pulmonology and Respiratory Medicine
• Clinical Research and Epidemiology
• Patient-Centered Outcomes Research

Background:

• Bronchiectasis is a chronic respiratory disease with rising prevalence and significant healthcare burden.
• Current knowledge gaps exist in its epidemiology, pathophysiology, and therapeutic options.
• There are no currently licensed therapies specifically for bronchiectasis.

Purpose of the Study:

• To establish consensus on critical research priorities for bronchiectasis.
• To integrate the perspectives of both clinical experts and patients with bronchiectasis.
• To guide future research efforts for better disease understanding and management.

Main Methods:

• A modified Delphi process involving European bronchiectasis experts (2014-2015).
• Consensus reached on 55 key research priorities by clinical experts.
• Patient and carer priorities collected via 711 questionnaires across 22 European countries.

Main Results:

• Integration of physician-identified and patient-identified research priorities.
• Identification of unique priorities from both expert and patient groups.
• A comprehensive list of research priorities serving as a clear roadmap.

Conclusions:

• The consensus statement provides a vital roadmap for bronchiectasis research.
• Addressing these priorities will enhance understanding of bronchiectasis pathophysiology.
• This research agenda aims to improve the quality of care for bronchiectasis patients.