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Published on: March 26, 2018
Asymmetrical proliferative pattern loss linked to cyclin D1 overexpression during malignant transformation of the lip
N G Garcia1,2, M A González-Moles2, I Ruiz-Ávila3
1Stomatology Department, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
Background:
There is inadequate knowledge on the involvement of oncogenic mechanisms linked to the cyclin (CCND1) gene in lip squamous cell carcinoma (LSCC).
Objective:
The aim of this study was to analyse the implication of cyclin D1 in the malignant transformation of lip lesions.
Methods:
We immunohistochemically studied 45 actinic cheilitis cases (15 mild dysplasia, 15 moderate dysplasia, 15 severe dysplasia/carcinoma in situ), 30 LSCC cases with adjacent non-tumour epithelium and 15 normal oral epithelium samples for detection of cyclin D1, β-catenin and Ki-67.
Results:
Cyclin D1 and Ki-67 expressions were significantly increased in the basal layer of premalignant epithelia and peripheral layers of tumour nests vs.
Controls:
Premalignant epithelia had lost their asymmetrical proliferative pattern.
Conclusion:
Lip carcinogenesis was associated with loss of the asymmetrical proliferative pattern, a preventive mechanism against lip oncogenesis, and with cyclin D1 overexpression.
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