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Updated: Mar 19, 2026

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
Published on: June 29, 2011
Mitochondria as a Signaling Hub and Target for Phenoptosis Shutdown
P V Zolotukhin1, A A Belanova, E V Prazdnova
1Southern Federal University, Academy of Biology and Biotechnology, Rostov-on-Don, 344090, Russia. vladimirchi@sfedu.ru.
Abstract:
Mitochondria have long been studied as the main energy source and one of the most important generators of reactive oxygen species in the eukaryotic cell. Yet, new data suggest mitochondria serve as a powerful cellular regulator, pathway trigger, and signal hub. Some of these crucial mitochondrial functions appear to be associated with RNP-granules. Deep and versatile involvement of mitochondria in general cellular regulation may be the legacy of parasitic behavior of the ancestors of mitochondria in the host cells. In this regard, we also discuss here the perspectives of using mitochondria-targeted compounds for systemic correction of phenoptotic shifts.
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