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[The Nephrological Aspects of the Use of Rivaroxaban and Other Direct Peroral Anticoagulants in Non-Valvular Atrial

M M Batiushin1

  • 1Federal state budgetary educational institution of higher education "Rostov state medical University" of the Ministry of health of the Russian Federation.

Kardiologiia
|June 28, 2019
PubMed

Insights

Chronic kidney disease (CKD) significantly increases cardiovascular risks, including atrial fibrillation (AF). This review covers AF treatment in CKD patients, focusing on direct oral anticoagulants versus warfarin.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Chronic kidney disease (CKD) is a major risk factor for cardiovascular events.
  • CKD is associated with increased risks of heart failure exacerbation, myocardial infarction, and cardiovascular mortality.
  • Atrial fibrillation (AF) is a notable adverse event in patients with CKD.

Purpose of the Study:

  • To discuss current therapeutic strategies for AF in patients across various stages of CKD.
  • To review the benefits of specific direct oral anticoagulants (DOACs) in this population.
  • To compare the efficacy and safety of DOACs with warfarin therapy.

Main Methods:

  • Literature review of current treatment approaches for AF in CKD.
  • Analysis of data on the benefits of DOACs in CKD patients.
  • Pharmacokinetic and pharmacodynamic evaluation of DOACs in relation to CKD.

Main Results:

  • DOACs offer benefits in managing AF in CKD patients.
  • Comparative data suggest specific DOACs may be advantageous over warfarin.
  • Understanding DOAC pharmacokinetics/pharmacodynamics is crucial for effective CKD therapy.

Conclusions:

  • Treatment of AF in CKD requires careful consideration of anticoagulation strategies.
  • DOACs represent a significant therapeutic option, with individualized selection based on CKD stage and drug properties.
  • Further research into optimal anticoagulation in CKD is warranted.

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