[Medico-genetic prediction of cerebral stroke risk]

A population family study including 1410 residents of Rostov region (280 families) was conducted. The study included questioning and analysis of medical records for the presence or absence of chronic diseases, including cardiovascular pathology, arterial hypertension, coronary heart disease, diabetes mellitus, and their complications, cerebral stroke (CS) and myocardial infarction, as well as the time of their occurrence. Statistic analysis included conventional descriptive statistics and regressive analysis, as well as a special part, population genetic analysis. The results showed that MI mortality was 21.4 times higher in the group of a high genotypic risk vs. the low risk group, 8.1 and 0.38%, respectively. The authors developed tools of MI risk prediction depending on hereditary burden, the use of which present a significant addition to the conventional system of phenotypic risk assessment. In order to adapt calculations to practical healthcare, the authors developed risk charts which allow MI risk assessment according to the magnitude of risk factors.