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Updated: Mar 19, 2026
08:38
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
17.6K
Reviewing 15 years of experience with sirolimus
Helio Tedesco Silva1, Claudia Rosso Felipe1, Jose Osmar Medina Pestana1
1Nephrology Division, Hospital do Rim, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Transplantation Research
|June 14, 2016
Summary
This review covers 15 years of sirolimus (SRL) use in kidney transplantation, showing comparable long-term outcomes with standard therapies. Further research is needed to optimize SRL
Area of Science:
- Nephrology
- Immunosuppression
- Transplantation
Background:
- Review of 15 years of clinical sirolimus (SRL) use in kidney transplantation.
- Contextualizes SRL within evolving global immunosuppressive strategies.
- Focus on de novo kidney transplant recipients.
Purpose of the Study:
- Evaluate long-term outcomes of sirolimus (SRL) in kidney transplantation.
- Explore steroid (ST) or calcineurin inhibitor (CNI)-sparing regimens.
- Identify areas for improving SRL's risk/benefit profile.
Main Methods:
- Retrospective review of clinical data.
- Analysis of SRL in combination with CNIs.
- Exploration of CNI minimization, elimination, or conversion strategies with mycophenolate (MMF/MPS).
Main Results:
- Pooled long-term outcomes comparable to CNI and antimetabolite combinations.
- Identified need for further investigation into SRL's risk/benefit profile.
- SRL associated with lower viral infections and malignancies.
Conclusions:
- Sirolimus (SRL) offers comparable long-term outcomes in kidney transplantation.
- Further research is essential for optimizing SRL therapy.
- Investigating drug interactions and adverse event mechanisms is crucial for improving SRL's risk/benefit profile.
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