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Published on: July 21, 2018
Practical considerations for the use of mTOR inhibitors
Fritz Diekmann1, Josep M Campistol2
1Department of Nephrology and Kidney Transplantation, Hospital Clínic, Villarroel, 170, E-08036 Barcelona, Spain ; Servicio de Nefrología - Clinical Institute of Nephrology and Urology, Hospital Clinic, Barcelona, Spain.
Abstract:
Immunosuppressive therapy after kidney transplantation is based on calcineurin inhibitors (CNI). In most cases CNI therapy is combined with mycophenolate and steroids. In spite of good short-term results this therapy is associated with long-term toxicities, graft loss and patient death. Therefore, alternative immunosuppressive strategies are needed that combine excellent efficacy with low incidences of long-term adverse outcomes. This review focuses on the strategies based on mTOR- inhibitors in combination with minimized exposure to CNI.
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