Synthesis of Chiral Oligomer-Grafted Biodegradable Polyurethanes and Their Chiral-Dependent Influence on Bone Marrow
Bin Hu1, Jun Deng1, Honghao Zheng1
1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Abstract:
Chirality is one of the most fascinating and ubiquitous features in nature, especially in biological systems. The effects of chiral surfaces, especially in combination with degradable materials of good biocompatibility, on stem cell behaviors has not yet been tackled. In this communication, the chiral monomers N-acryloyl-l(d)-valine (l(d)-AV) are synthesized and are polymerized to obtain chiral (l(d)-PAV-SH) oligomers, which are covalently immobilized onto electron-deficient poly(propylene fumarate) polyurethane (PPFU) via Michael addition. The PPFU-l-PAV can interact more strongly and actively with bone marrow stem cells (BMSCs) than PPFU-d-PAV, leading to a larger cell spreading area, faster migration velocity, and stronger osteodifferentiation tendency.
