Related Experiment Video

Updated: Mar 19, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

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[AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE: HOW AND WHY SHOULD WE IDENTIFY THE PATIENTS "RAPIDLY PROGRESSING" TO

A Bodson, P Meunier, J-M Krzesinski

    Revue Medicale De Liege
    |June 15, 2016
    PubMed

    Insights

    Autosomal dominant polycystic kidney disease (ADPKD) is an inherited condition causing kidney cysts and often leading to kidney failure. Identifying rapid progressors aids in early intervention and management to slow disease advancement.

    Area of Science:

    • Nephrology
    • Genetics
    • Internal Medicine

    Context:

    • Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent inherited disorder.
    • ADPKD is characterized by bilateral kidney cyst development, frequently leading to end-stage renal disease (ESRD).
    • Early identification of "rapid progressors" is crucial for managing ADPKD and mitigating ESRD risks.

    Purpose:

    • To outline current methods for assessing ADPKD progression.
    • To discuss the efficacy of tolvaptan in slowing cyst growth and GFR decline.
    • To review current ADPKD management strategies focused on risk factor modification.

    Summary:

    • ADPKD progression is evaluated using clinical scores (PROPKD-Score), biological markers (GFR decline, creatinine doubling), and radiological criteria (TKV, TKV growth rate).
    • While no cure exists, vasopressin-2 receptor antagonists like tolvaptan show promise in slowing renal cyst growth and GFR decline.
    • Current ADPKD management involves addressing risk factors such as hydration, blood pressure, and smoking cessation.

    Impact:

    • This information aids clinicians in identifying high-risk ADPKD patients for timely intervention.
    • Understanding progression markers and treatment options can improve patient outcomes and slow the development of ESRD.
    • The review highlights the importance of a multi-faceted approach to ADPKD management, combining risk factor control with emerging therapies.

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