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Updated: Mar 19, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
LAP: the protector against autoimmunity
Urmi Bandyopadhyay1, Michael Overholtzer1
1Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Abstract:
The autophagy-related process LC3-Associated Phagocytosis, or LAP, is known to control the degradation of engulfed cells and microorganisms. Now Martinez et al. discover that LAP controls immune responses to dying cells and its inhibition leads to development of Systemic Lupus Erythematosus-like disease.
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