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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Cell-mediated Immune Responses01:40

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
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What is the Immune System?01:38

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Related Experiment Video

Updated: Mar 19, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

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LAP: the protector against autoimmunity.

Urmi Bandyopadhyay1, Michael Overholtzer1

  • 1Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell Research
|June 15, 2016
PubMed
Summary
This summary is machine-generated.

LC3-Associated Phagocytosis (LAP) degrades cellular waste and controls immune responses to dying cells. Inhibiting LAP in mice triggers a Systemic Lupus Erythematosus-like autoimmune disease, revealing LAP

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Related Experiment Videos

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Area of Science:

  • Immunology
  • Cell Biology
  • Autophagy

Background:

  • LC3-Associated Phagocytosis (LAP) is an autophagy-related process crucial for degrading engulfed materials.
  • The role of LAP in regulating immune responses to cellular debris, particularly dying cells, remains incompletely understood.

Purpose of the Study:

  • To investigate the function of LAP in the immune response to dying cells.
  • To determine the consequences of LAP inhibition on immune homeostasis and disease development.

Main Methods:

  • Utilized genetic and pharmacological approaches to inhibit LAP in a mouse model.
  • Assessed immune cell populations, autoantibody production, and clinical manifestations.

Main Results:

  • LAP was found to be essential for the proper immune handling of dying cells.
  • Inhibition of LAP led to the spontaneous development of a disease resembling human Systemic Lupus Erythematosus (SLE).
  • This SLE-like disease was characterized by autoantibody production and systemic inflammation.

Conclusions:

  • LAP plays a critical role in preventing autoimmunity by ensuring the efficient clearance of dying cells.
  • Dysregulation or inhibition of LAP can precipitate autoimmune conditions like SLE.
  • Targeting LAP may offer a novel therapeutic strategy for autoimmune diseases.