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Yes, It is Possible.

Gautam N Allahbadia1

  • 1Rotunda-The Center For Human Reproduction, Mumbai, India.

Journal of Obstetrics and Gynaecology of India
|June 15, 2016
PubMed
Summary

Human immunodeficiency virus (HIV)-serodiscordant couples can safely achieve pregnancy using assisted reproduction techniques. Sperm washing and other advanced methods minimize infection risk for partners, enabling family completion.

Area of Science:

  • Reproductive Medicine
  • Infectious Diseases
  • Genetics

Background:

  • Human immunodeficiency virus (HIV)-serodiscordant couples face unique reproductive challenges.
  • Unsafe conception practices are common due to unmet reproductive needs.
  • Assisted reproduction offers a safe alternative for family building.

Purpose of the Study:

  • To review reproductive assistance options for HIV-serodiscordant couples.
  • To highlight the safety and efficacy of assisted reproduction techniques.
  • To discuss risk mitigation strategies in managing HIV during conception.

Main Methods:

  • Review of published literature on assisted reproduction for HIV-serodiscordant couples since 1987.
  • Analysis of techniques including sperm washing, intrauterine insemination (IUI), in vitro fertilization (IVF), and intracytoplasmic sperm injection (ICSI).
Keywords:
HIVHepatitis C VirusHuman immunodeficiency virus-serodiscordant couplesTransmission of virus

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  • Examination of laboratory protocols and safety measures for handling gametes from HIV-positive individuals.
  • Main Results:

    • Over 4000 reported pregnancy attempts using processed sperm from HIV-positive men.
    • IUI is effective for preventing horizontal transmission when the female partner is HIV-positive.
    • Sperm washing techniques minimize infection risk when the male partner is HIV-positive.
    • Advanced reproductive technology (ART) addresses underlying infertility.
    • Pre-exposure prophylaxis (PrEP) further reduces susceptibility.
    • No reported cases of laboratory personnel infection or cross-contamination with established protocols.

    Conclusions:

    • Assisted reproduction techniques are safe and effective for HIV-serodiscordant couples.
    • Specialized laboratory procedures ensure the safety of gamete/embryo processing.
    • ART and PrEP offer comprehensive solutions for family completion in HIV-serodiscordant couples.