Systemic Delivery and Biodistribution of Cisplatin in Vivo
Yu-Hsuan Chu1, Martha Sibrian-Vazquez1, Jorge O Escobedo1
1Department of Chemistry, Portland State University , Portland, Oregon 97201, United States.
Abstract:
Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.
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